Why is an anti-double strand DNA test done?

What Is Anti Ds-DNA Antibody Test?

Anti Ds-DNA antibody is a kind of DNA blood test that is used to diagnose lupus or more aptly the SLE. If a patient has a positive ANA test outcome plus shows symptoms identical to that of lupus, the ELISA test is highly suggested. ELISA or more aptly enzyme-linked immunosorbent assay is commonly used to detect these antibodies in the blood.

Why Do I Need Anti Ds-DNA Antibody Test?

ELISA DNA test procedure aids in distinguishing lupus from other autoimmune illnesses that may have been bothering you. The DNA test analysis also assists in measuring the severity of the diseases in patients detected with lupus and lupus nephritis too.

If you are encountering muscle pain, hair loss, weight loss, arthritis, weakness, fever, exhaustion, numbness in the feet or the hands, or even organ inflammation or damage; lupus is what is suspected. A DNA blood test is what you require in this case.

Lupus nephritis is a severe form of lupus condition that can guide inflammation and kidney issues. Therefore, DNA antibody testing becomes necessary before it is too late.

What Do My Test Results Mean?

First, the ANA test result is examined. If a positive result is received, the ELISA DNA test is conducted for ruling out anti-ds DNA in the blood. If that outcome also comes out to be positive; lupus is inferred.

If the level of anti-ds DNA is found to be high, lupus nephritis is normally concluded. Moderate levels of anti-ds DNA antibody are thought to be associated with autoimmune illnesses like Sjogren syndrome or mixed connective tissue disease (MCTD).

And, when the DNA results indicate low levels of anti-ds DNA, it suggests that you may not be into that much trouble. But that nowhere represents that lupus has no role to play in your condition.

Statistics indicate that only about 50-70% suffering from lupus are detected with anti-ds DNA.

How Is This Anti-Ds-Dna Antibody Done?

As far as how to do a DNA test is affected, enzyme-linked immunosorbent assay or ELISA is conducted. In this anti-ds test, antibodies and colour modifications are used to identify foreign substances. The DNA test approach involves the collection of the blood sample that would be added to the test apparatus containing antigens.

In case your blood test has got antibodies to the specific antigens, both of them would bind together. Next, an enzyme would be added to the cohered antigens and antibodies to examine for colour changes. If the lab technician detected a change in colour, you would be having anti-ds DNA in your blood.

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